Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 19/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 19/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 13/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603094 | 0.96 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL6599112 | 0.89 | MAPK1 (0.42) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL6598738 | 0.84 | F10 (0.38) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL6598659 | 0.82 | UTS2R (0.39) | SLC6A2SLC6A4CYP2D6KCNH2MAPK1 | |
| SCHEMBL6598651 | 0.82 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL6599638 | 0.81 | F10 (0.39) | SLC6A2SLC6A4 | |
| SCHEMBL6600076 | 0.80 | F10 (0.36) | SLC6A2SLC6A4 | |
| SCHEMBL6603092 | 0.77 | SLC6A2 (0.32) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL6599108 | 0.71 | MAPK1 (0.39) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL6193475 | 0.71 | UTS2R (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379503-A1 | PYRROLIDINE SULFONAMIDES | SmithKline Beecham Corporation (US) | 2004-01-14 | — | — | EP | claimed |
| WO-2002079155-A1 | PYRROLIDINE SULFONAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | claimed |
| EP-1379503-A1 | PYRROLIDINE SULFONAMIDES | SmithKline Beecham Corporation (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002079155-A1 | PYRROLIDINE SULFONAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | disclosed |