Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.34 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615944 | 0.97 | ALDH1A1 (0.43) | ALDH1A1GAATP53KMT2AMEN1 | |
| SCHEMBL6619394 | 0.92 | ALDH1A1 (0.45) | ALDH1A1GAATP53KMT2AMEN1 | |
| SCHEMBL6630940 | 0.91 | KMT2A (0.41) | GAAKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL6618271 | 0.89 | MAPT (0.41) | GAATP53KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6619894 | 0.89 | KMT2A (0.39) | ALDH1A1GAAKMT2AMEN1CYP1A2 | |
| SCHEMBL6616552 | 0.88 | NPY2R (0.36) | GAAKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL6620324 | 0.88 | NPY2R (0.36) | GAAKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL6617374 | 0.87 | TP53 (0.39) | ALDH1A1GAATP53KMT2AMEN1 | |
| SCHEMBL6604966 | 0.86 | KMT2A (0.42) | GAAKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL6617183 | 0.86 | ALDH1A1 (0.40) | ALDH1A1TP53SMN1; SMN2AADATP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | disclosed |