Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.36 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.36 |
| ▸ | MCTS1 | Q9ULC4 | 2/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.36 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.36 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616528 | 0.91 | TP53 (0.38) | ALDH1A1SMN1; SMN2L3MBTL1HPGDP2RX4 | |
| SCHEMBL6619186 | 0.91 | MEN1 (0.38) | ALDH1A1SMN1; SMN2MAPTL3MBTL1HPGD | |
| SCHEMBL6617727 | 0.90 | GNRHR (0.39) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL6615944 | 0.90 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2HPGDP2RX7TP53 | |
| SCHEMBL6616621 | 0.88 | SMN1; SMN2 (0.40) | ALDH1A1SMN1; SMN2MAPTHPGDNPC1 | |
| SCHEMBL6618271 | 0.88 | MAPT (0.41) | SMN1; SMN2MAPTTP53RAB9ACNR1 | |
| SCHEMBL6617374 | 0.88 | TP53 (0.39) | ALDH1A1SMN1; SMN2MAPTL3MBTL1HPGD | |
| SCHEMBL6619198 | 0.88 | CRACR2A (0.44) | SMN1; SMN2MAPTTP53 | |
| SCHEMBL6660284 | 0.88 | ACKR3 (0.42) | SMN1; SMN2MAPTL3MBTL1TP53NPC1 | |
| SCHEMBL6617068 | 0.87 | PKM (0.38) | ALDH1A1SMN1; SMN2MAPTL3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |