SCHEMBL6603490

SCHEMBL6603490

CC(=O)C=Cc1cccc(C)c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.62
GLA P06280 1/20 0.62
MAOA P21397 2/20 0.59
MAOB P27338 2/20 0.59
PTGS1 P23219 2/20 0.55
IAPP P10997 1/20 0.55
ALOX5 P09917 1/20 0.53
PTGS2 P35354 1/20 0.53
FBP1 P09467 1/20 0.51
MMP1 P03956 3/20 0.51
MMP2 P08253 3/20 0.51
MMP9 P14780 3/20 0.51
EGFR P00533 1/20 0.51
MAPT P10636 2/20 0.50
NPC1 O15118 2/20 0.50
KDM4E B2RXH2 1/20 0.50
MEN1 O00255 1/20 0.50
ALDH1A1 P00352 1/20 0.50
LMNA P02545 1/20 0.50
POLB P06746 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8948080 1.00 TDP1 (0.62) TDP1GLAMAOAMAOBPTGS1
SCHEMBL14441060 0.88 GLA (0.72) TDP1GLAPTGS1IAPPMAPT
SCHEMBL5599097 0.86 CYP1A2 (0.61) TDP1MAOAMAOBPTGS1ALOX5
SCHEMBL5599099 0.86 CYP1A2 (0.61) TDP1MAOAMAOBPTGS1ALOX5
SCHEMBL79073 0.85 NPSR1 (0.62) TDP1GLAMAOAMAOBPTGS1
SCHEMBL79074 0.85 NPSR1 (0.62) TDP1GLAMAOAMAOBPTGS1
SCHEMBL9714866 0.85 NPSR1 (0.62) TDP1GLAMAOAMAOBPTGS1
SCHEMBL29426419 0.85 NPSR1 (0.62) TDP1GLAMAOAMAOBPTGS1
SCHEMBL31202444 0.83 MAOA (0.62) TDP1MAOAMAOBPTGS1ALOX5
SCHEMBL6752531 0.83 MAOA (0.62) TDP1MAOAMAOBPTGS1ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102300550-A Perfume systems 2011-12-28 CN claimed
CN-119528983-A Method for green catalytic synthesis of gamma-ketophosphine oxide by asymmetric alkylaluminum compound 北京理工大学 2025-02-28 CN disclosed
CN-115232019-B Synthesis method of 3-acetamido benzotrifluoride compound 闽江学院 2023-10-27 CN disclosed
CN-115232019-A Synthetic method of 3-acetamido benzotrifluoride compound 闽江学院 2022-10-25 CN disclosed
EP-1458679-A2 PYRROLIDINE DERIVATIVES AS PROSTAGLANDIN MODULATORS Applied Research Systems ARS Holding N.V. (AN) 2004-09-22 EP disclosed
EP-1439837-A1 PYRAZOLIDINONE COMPOUNDS AS LIGANDS OF THE PROSTAGLANDIN EP2 AND/OR EP4 RECEPTORS Applied Research Systems ARS Holding N.V. (AN) 2004-07-28 EP disclosed
WO-2003053923-A2 PYRROLIDINE DERIVATIVES AS PROSTAGLANDIN MODULATORS APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2003-07-03 WO disclosed
WO-2003035064-A1 PYRAZOLIDINONE COMPOUNDS AS LIGANDS OF THE PROSTAGLANDIN EP2 AND/OR EP4 RECEPTORS APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2003-05-01 WO disclosed
US-5484949-A Method for the synthesis of α β-unsaturated ketones NIPPON SODA CO., LTD. (JP) 1996-01-16 US disclosed
EP-0454867-A1 A METHOD FOR THE SYNTHESIS OF -g(a), -g(b)-UNSATURATED KETONES. NIPPON SODA CO (JP) 1991-11-06 EP disclosed
WO-1991007370-A1 A METHOD FOR THE SYNTHESIS OF α, β-UNSATURATED KETONES NIPPON SODA CO., LTD. (JP) 1991-05-30 WO disclosed
US-3989708-A HYPOTENSIVE, CORONARY VESSEL DILATORS BAYER AKTIENGESELLSCHAFT (DT) 1976-11-02 US disclosed