Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 6/20 | 0.62 |
| ▸ | FNTA | P49354 | 11/20 | 0.50 |
| ▸ | FNTB | P49356 | 11/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5758052 | 0.85 | GRIA4 (0.64) | GRIA4FNTAFNTBKDM4EALDH1A1 | |
| SCHEMBL16792140 | 0.80 | GRIA4 (0.64) | GRIA4FNTAFNTBKMT2A | |
| SCHEMBL9865335 | 0.79 | GRIA4 (0.48) | GRIA4FNTAFNTBKDM4EALDH1A1 | |
| SCHEMBL10652875 | 0.79 | GRIA4 (0.74) | GRIA4FNTAFNTBGRIA2KMT2A | |
| SCHEMBL3128889 | 0.77 | GRIA4 (1.00) | GRIA4FNTAFNTBGRIA2KMT2A | |
| SCHEMBL9865583 | 0.76 | GRIA4 (0.48) | GRIA4FNTAFNTBKDM4EALDH1A1 | |
| SCHEMBL3131105 | 0.76 | GRIA4 (0.76) | GRIA4FNTAFNTBGRIA2 | |
| SCHEMBL9865423 | 0.75 | MEN1 (0.48) | GRIA4FNTAFNTBKDM4EALDH1A1 | |
| SCHEMBL9141734 | 0.74 | GRIA4 (0.51) | GRIA4FNTAFNTBGRIA2KMT2A | |
| SCHEMBL5756967 | 0.74 | GRIA4 (0.62) | GRIA4FNTAFNTBKDM4EGRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1389206-A2 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES | Vertex Pharmaceuticals Incorporated (US) | 2004-02-18 | — | — | EP | disclosed |
| WO-2002083667-A2 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-10-24 | — | — | WO | disclosed |