Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | EIF4EBP1 | Q13541 | 5/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ICMT | O60725 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601564 | 0.90 | KDM4E (0.36) | ADORA1EIF4EBP1ADORA2AICMTALDH1A1 | |
| SCHEMBL6805250 | 0.87 | ICMT (0.42) | EIF4EBP1ICMTPDE5ASMN1; SMN2LMNA | |
| SCHEMBL6607058 | 0.86 | ADORA1 (0.41) | NCEH1ADORA1ADORA2AALDH1A1HTT | |
| SCHEMBL6602524 | 0.77 | ADORA1 (0.40) | NCEH1ADORA1ADORA2AALDH1A1HTT | |
| SCHEMBL6602658 | 0.76 | HPGD (0.42) | ALDH1A1SMN1; SMN2LMNAMAPTHPGD | |
| SCHEMBL6604163 | 0.76 | S1PR4 (0.40) | ADORA1ALDH1A1HTTSMN1; SMN2MAPT | |
| SCHEMBL6606370 | 0.76 | SCN9A (0.38) | ADORA1EIF4EBP1ADORA2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6604165 | 0.75 | MAPT (0.46) | ADORA1ADORA2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6805998 | 0.74 | HPGD (0.41) | ALDH1A1SMN1; SMN2LMNAMAPTHPGD | |
| SCHEMBL6603514 | 0.74 | NLRP3 (0.41) | EIF4EBP1SMN1; SMN2LMNAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040180891-A1 | Pyrazole derivatives useful in the treatment of hyper-proliferative disorders | BAYER PHARMACEUTICALS CORPORATION | 2004-09-16 | — | — | US | disclosed |
| EP-1432689-A1 | PYRAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS | Bayer Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027074-A1 | PYRAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180891-A1 | Pyrazole derivatives useful in the treatment of hyper-proliferative disorders | MKI67, CDK4, FLT4 | NCEH1 3856/4885ADORA1 3424/4885EIF4EBP1 2524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.