Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9870670 | 1.00 | MEN1 (0.32) | MEN1KMT2AHTTPDCD1CD274 | |
| SCHEMBL9865636 | 1.00 | MEN1 (0.32) | MEN1KMT2AHTTPDCD1CD274 | |
| SCHEMBL6386752 | 0.89 | BACE1 (0.31) | — | |
| SCHEMBL5747380 | 0.89 | BACE1 (0.31) | — | |
| SCHEMBL5505248 | 0.79 | — | — | |
| SCHEMBL24535769 | 0.73 | ALDH1A1 (0.36) | PDCD1CD274 | |
| SCHEMBL12512988 | 0.73 | ALDH1A1 (0.36) | PDCD1CD274 | |
| SCHEMBL24535774 | 0.73 | ALDH1A1 (0.36) | PDCD1CD274 | |
| SCHEMBL367375 | 0.71 | — | — | |
| SCHEMBL14749809 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100371322-C | 2-pyrrolidone derivatives as prostanoid agonists | HOFFMAN ROCHE AG F (CH) | 2008-02-27 | — | — | CN | disclosed |
| CN-1529593-A | 2-pyrrolidone derivatives as prostanoid agonists | - | 2004-09-15 | — | — | CN | disclosed |
| EP-1408961-A1 | 2 PYRROLIDONE DERIVATIVES AS PROSTANOID AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003007941-A1 | 2 PYRROLIDONE DERIVATIVES AS PROSTANOID AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-01-30 | — | — | WO | disclosed |