Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13083665 | 0.86 | GAA (0.50) | PKMSMN1; SMN2MAPTALDH1A1KMT2A | |
| SCHEMBL5177500 | 0.85 | PKM (0.68) | PKMSMN1; SMN2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL8914837 | 0.84 | PKM (0.63) | PKMCHEK1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL9936651 | 0.84 | PKM (0.63) | PKMCHEK1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL261412 | 0.80 | PKM (0.61) | PKMSMN1; SMN2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL17704088 | 0.79 | GPR84 (0.49) | MAPTALDH1A1KMT2AMEN1GAA | |
| SCHEMBL9662401 | 0.79 | PKM (0.56) | PKMSMN1; SMN2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL9437539 | 0.78 | PKM (0.55) | PKMCHEK1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL361312 | 0.77 | PKM (1.00) | PKMSMN1; SMN2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL30419025 | 0.77 | PKM (1.00) | PKMSMN1; SMN2CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004101533-A1 | 1, 3, 4-BENZOTRIAZEPIN-2-ONE SALTS AND THEIR USE AS CCK RECEPTOR LIGANDS | JANSSEN PHARMACEUTICA, N.V. (US) | 2004-11-25 | — | — | WO | disclosed |
| EP-1443934-A1 | BENZOTRIAZEPINES AS GASTRIN AND CHOLECYSTOKININ RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003041714-A1 | BENZOTRIAZEPINES AS GASTRIN AND CHOLECYSTOKININ RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 2003-05-22 | — | — | WO | disclosed |