Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.43 |
| ▸ | FPR2 | P25090 | 2/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606823 | 0.84 | RBP4 (0.45) | KDM4EMAPTTHRBGPR119PTPN2 | |
| SCHEMBL31222908 | 0.82 | MAPT (0.51) | KDM4EMAPTTHRBGPR119FPR2 | |
| SCHEMBL23291499 | 0.81 | STS (0.50) | KDM4EMAPTTHRBGPR119FPR2 | |
| SCHEMBL26930284 | 0.81 | GPR119 (0.56) | KDM4EMAPTTHRBGPR119FPR2 | |
| SCHEMBL23291507 | 0.81 | MAPT (0.49) | KDM4EMAPTTHRBGPR119FPR2 | |
| SCHEMBL31222846 | 0.81 | MAPT (0.49) | KDM4EMAPTTHRBGPR119FPR2 | |
| SCHEMBL31192673 | 0.80 | MAPT (0.51) | KDM4EMAPTTHRBGPR119FPR2 | |
| SCHEMBL7672542 | 0.80 | SMN1; SMN2 (0.51) | USP30HTT | |
| SCHEMBL6608980 | 0.80 | SMN1; SMN2 (0.51) | USP30HTT | |
| SCHEMBL34466611 | 0.80 | KDM4E (0.48) | KDM4EMAPTTHRBGPR119FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119551-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1433783-A2 | Naphthalenecarboxamides as tachykinin receptor antagonists | AstraZeneca AB (SE) | 2004-06-30 | — | — | EP | disclosed |
| CN-1322196-A | Naphthalenecarboxamides as tachykinin receptor antagonists | ASTRA ZENECA N N (SE) | 2001-11-14 | — | — | CN | disclosed |