SCHEMBL6604582

SCHEMBL6604582

CCc1sc(-c2ccc(F)cc2)nc1CC(=O)O

nearest known ligand 0.60

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 11/20 0.60
DCK P27707 1/20 0.53
LMNA P02545 2/20 0.51
TP53 P04637 1/20 0.47
MAPT P10636 1/20 0.47
KDM4E B2RXH2 1/20 0.47
POLB P06746 1/20 0.47
TRPM8 Q7Z2W7 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.45
FFAR1 O14842 1/20 0.45
PPARD Q03181 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6608210 0.87 PTGDR2 (0.63) PTGDR2KDM4EPOLBTRPM8L3MBTL1
SCHEMBL4479582 0.85 PPARD (0.56) PTGDR2MAPTKDM4EFFAR1PPARD
SCHEMBL9555733 0.80 PTGDR2 (0.59) PTGDR2LMNAKDM4EPOLB
SCHEMBL6602682 0.80 DCK (0.55) PTGDR2DCKLMNATP53MAPT
SCHEMBL18003089 0.74 L3MBTL1 (0.76) PTGDR2DCKLMNATP53MAPT
SCHEMBL13116312 0.73 PTGDR2 (0.81) PTGDR2KDM4EPOLB
SCHEMBL13116436 0.73 PTGDR2 (0.48) PTGDR2LMNAMAPTKDM4E
SCHEMBL18003092 0.72 DCK (0.47) PTGDR2DCKLMNATP53MAPT
SCHEMBL28786381 0.71 KDM4E (0.49) PTGDR2LMNAMAPTKDM4E
SCHEMBL4473367 0.71 MAPT (0.57) MAPTKDM4EPOLBTRPM8FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1102757-B1 SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS GLAXO GROUP LTD (GB) 2004-04-14 EP disclosed
US-6498174-B1 AGONISTS TO PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; MODULATING BLOOD GLUCOSE AND LIPID LEVELS; REDUCING DYSLIPIDEMIA AND HYPERINSULINEMIA ASSOCIATED WITH IMPAIRED GLUCOSE TOLERANCE OR METABOLIC SYNDROME SMITHKLINE BEECHAM CORPORATION 2002-12-24 US disclosed
EP-1102757-A1 SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS GLAXO GROUP LIMITED (GB) 2001-05-30 EP disclosed
WO-2000008002-A1 SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS hPPAR GAMMA AND hPPAR ALPHA ACTIVATORS GLAXO GROUP LIMITED (GB) 2000-02-17 WO disclosed