Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6324214 | 0.91 | CYP3A4 (0.34) | CYP3A4KDM4ECHRM1MAPTFKBP1A | |
| SCHEMBL6605366 | 0.90 | CYP3A4 (0.34) | CYP3A4KDM4ECHRM1MAPTFKBP1A | |
| SCHEMBL6609747 | 0.88 | FKBP1A (0.33) | CYP3A4KDM4ECHRM1MAPTFKBP1A | |
| SCHEMBL6606308 | 0.88 | CYP3A4 (0.33) | CYP3A4KDM4ECHRM1MAPTFKBP1A | |
| SCHEMBL6328305 | 0.87 | NR1H2 (0.36) | CYP3A4KDM4ECHRM1MAPTFKBP1A | |
| SCHEMBL6791730 | 0.87 | NR1H2 (0.36) | CYP3A4KDM4ECHRM1MAPTFKBP1A | |
| SCHEMBL6608741 | 0.87 | CHRM1 (0.32) | CYP3A4KDM4ECHRM1MAPT | |
| SCHEMBL6610324 | 0.86 | ALDH1A1 (0.32) | CYP3A4KDM4ETSHRALDH1A1 | |
| SCHEMBL6605662 | 0.86 | JAK1 (0.35) | CYP3A4KDM4E | |
| SCHEMBL6608201 | 0.85 | CYP3A4 (0.34) | CYP3A4KDM4ECHRM1MAPTFKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590789-B9 | Excitatory amino acid receptor antagonists | LILLY CO ELI (US) | 2004-02-04 | — | — | EP | disclosed |
| EP-0590789-B1 | Excitatory amino acid receptor antagonists | LILLY CO ELI (US) | 2003-03-12 | — | — | EP | disclosed |
| US-5675008-A | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1997-10-07 | — | — | US | disclosed |
| US-5670516-A | NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1997-09-23 | — | — | US | disclosed |
| US-5648492-A | Process for preparing isoquinoline compounds | ELI LILLY AND COMPANY (US) | 1997-07-15 | — | — | US | disclosed |
| US-5637712-A | CATALYTIC HYDROGENNATION | ELI LILLY AND COMPANY (US) | 1997-06-10 | — | — | US | disclosed |
| US-5606062-A | STEREOSELECTIVE REDUCTION | ELI LILLY AND COMPANY (US) | 1997-02-25 | — | — | US | disclosed |
| US-5399696-A | Excitatory amino acid receptor antagonists; nervous system disorders | ELI LILLY AND COMPANY (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0590789-A1 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1994-04-06 | — | — | EP | disclosed |
| US-5284957-A | Substituted 1H- or 2H-tetrazoles | ELI LILLY AND COMPANY (US) | 1994-02-08 | — | — | US | disclosed |