Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606776 | 0.94 | HRH1 (0.56) | HRH1CACNA1GHTR2AHTR2CHTR7 | |
| SCHEMBL6606267 | 0.89 | HRH1 (0.64) | HRH1 | |
| SCHEMBL6604991 | 0.81 | HRH1 (0.46) | HRH1HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL6603645 | 0.81 | HRH1 (0.41) | HRH1CACNA1G | |
| SCHEMBL11684829 | 0.80 | DRD2 (0.67) | HRH1HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL6604479 | 0.78 | HRH1 (0.42) | HRH1 | |
| SCHEMBL17023772 | 0.78 | HRH1 (0.77) | HRH1 | |
| SCHEMBL17023764 | 0.78 | HRH1 (0.77) | HRH1 | |
| SCHEMBL6607904 | 0.77 | HRH1 (0.44) | HRH1 | |
| SCHEMBL11103654 | 0.76 | CHRM3 (0.42) | L3MBTL1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756370-B1 | POTENT 5-HT2A RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2004-06-29 | — | — | US | disclosed |
| EP-1202966-B1 | PIPERIDINE ALCOHOLS | MERCK PATENT GMBH (DE) | 2004-06-09 | — | — | EP | disclosed |
| EP-1202966-A1 | PIPERIDINE ALCOHOLS | MERCK PATENT GmbH (DE) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001014332-A1 | PIPERIDINE ALCOHOLS | MERCK PATENT GMBH (DE) | 2001-03-01 | — | — | WO | disclosed |