Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606776 | 0.82 | HRH1 (0.56) | HRH1 | |
| SCHEMBL6603645 | 0.81 | HRH1 (0.41) | HRH1KCNH2 | |
| SCHEMBL6606267 | 0.80 | HRH1 (0.64) | HRH1KCNH2 | |
| SCHEMBL6605503 | 0.77 | HRH1 (0.51) | HRH1 | |
| SCHEMBL11103654 | 0.74 | CHRM3 (0.42) | — | |
| SCHEMBL6603656 | 0.74 | HTR2A (0.51) | HRH1SIGMAR1OPRK1KCNH2 | |
| SCHEMBL13621141 | 0.73 | HRH3 (0.60) | SIGMAR1HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL15866342 | 0.73 | HRH3 (0.52) | HRH3OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL6605812 | 0.72 | HRH1 (0.51) | HRH1KCNH2 | |
| SCHEMBL6604479 | 0.71 | HRH1 (0.42) | HRH1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1170819-C | Piperidine alcohols | Ĭ��ר���ɷ�����˾ | 2004-10-13 | — | — | CN | disclosed |
| US-6756370-B1 | POTENT 5-HT2A RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2004-06-29 | — | — | US | disclosed |
| EP-1202966-B1 | PIPERIDINE ALCOHOLS | MERCK PATENT GMBH (DE) | 2004-06-09 | — | — | EP | disclosed |
| CN-1371365-A | Piperidine alcohols | MERCK PATENT GMBH (DE) | 2002-09-25 | — | — | CN | disclosed |
| EP-1202966-A1 | PIPERIDINE ALCOHOLS | MERCK PATENT GmbH (DE) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001014332-A1 | PIPERIDINE ALCOHOLS | MERCK PATENT GMBH (DE) | 2001-03-01 | — | — | WO | disclosed |