Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | IDE | P14735 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6607034 | 0.94 | MAPT (0.50) | MCHR1MAPTLMNAMEN1KMT2A | |
| SCHEMBL6603016 | 0.93 | MCHR1 (0.62) | MCHR1MAPTLMNAMEN1KMT2A | |
| SCHEMBL6607021 | 0.89 | MCHR1 (0.54) | MCHR1MAPTLMNAMEN1KMT2A | |
| SCHEMBL6603809 | 0.87 | MCHR1 (0.54) | MCHR1MAPTLMNAMEN1KMT2A | |
| SCHEMBL6602984 | 0.85 | MCHR1 (0.49) | MCHR1MAPTTLR7KDM4ENPC1 | |
| SCHEMBL6606577 | 0.85 | ALDH1A1 (0.53) | MCHR1MAPTLMNATLR7MAPK1 | |
| SCHEMBL6603115 | 0.84 | MCHR1 (0.48) | MCHR1MAPTLMNAMEN1KMT2A | |
| SCHEMBL6603151 | 0.84 | MCHR1 (0.50) | MCHR1MAPTLMNATLR7KDM4E | |
| SCHEMBL7723576 | 0.84 | MAPT (0.53) | MCHR1MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL6602624 | 0.82 | NPSR1 (0.54) | MCHR1MAPTLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102535-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| US-6399656-B1 | USING A BENZOPYRAN-3-CARBOXAMIDE COMPOUND | SMITHKLINE BEECHAM CORPORATION | 2002-06-04 | — | — | US | disclosed |
| EP-1102535-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000006085-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |