Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | IDE | P14735 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6605795 | 0.94 | MCHR1 (0.53) | MAPTLMNAMEN1KMT2ATLR7 | |
| SCHEMBL6603809 | 0.93 | MCHR1 (0.54) | MAPTLMNAMEN1KMT2ATLR7 | |
| SCHEMBL6607021 | 0.88 | MCHR1 (0.54) | MAPTLMNAMEN1KMT2ATLR7 | |
| SCHEMBL6603016 | 0.87 | MCHR1 (0.62) | MAPTLMNAMEN1KMT2ATLR7 | |
| SCHEMBL6602784 | 0.85 | MAPT (0.45) | MAPTMEN1KMT2ATLR7MAPK1 | |
| SCHEMBL6602620 | 0.85 | ALDH1A1 (0.52) | MAPTLMNATLR7MAPK1IDE | |
| SCHEMBL6604151 | 0.85 | TLR7 (0.46) | MAPTLMNATLR7KDM4ERAB9A | |
| SCHEMBL6604870 | 0.84 | MAPT (0.52) | MAPTMEN1KMT2AMAPK1KDM4E | |
| SCHEMBL6604075 | 0.84 | IRAK4 (0.56) | MAPTLMNAMEN1KMT2ATLR7 | |
| SCHEMBL6602569 | 0.83 | MCHR1 (0.65) | MAPTMEN1KMT2AMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102535-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-1102535-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000006085-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |