Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 14/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | HCK | P08631 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1539959 | 0.80 | LCK (0.58) | LCKMAPK14MAPK13EGFRFYN | |
| SCHEMBL17571955 | 0.79 | LCK (0.61) | LCKMAPK14MAPK13EGFRFYN | |
| SCHEMBL31052681 | 0.78 | LCK (0.60) | LCKMAPK14MAPK13EGFRFYN | |
| SCHEMBL6603764 | 0.77 | LCK (0.56) | LCK | |
| SCHEMBL1540066 | 0.76 | LCK (0.68) | LCKMAPK14MAPK13EGFRFYN | |
| SCHEMBL774476 | 0.74 | MAPK14 (0.84) | LCKMAPK14MAPK13EGFRFYN | |
| SCHEMBL774121 | 0.72 | MAPK14 (0.66) | LCKMAPK14MAPK13EGFRFYN | |
| SCHEMBL774143 | 0.72 | LCK (0.72) | LCKMAPK14MAPK13EGFRFYN | |
| SCHEMBL29616014 | 0.72 | MAPK14 (0.67) | LCKMAPK14MAPK13EGFRFYN | |
| SCHEMBL1540030 | 0.72 | MAPK14 (0.67) | LCKMAPK14MAPK13EGFRFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169038-A4 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2004-10-13 | — | — | EP | disclosed |
| EP-1169038-A1 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000062778-A1 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB CO. (US) | 2000-10-26 | — | — | WO | disclosed |