Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6605980 | 0.87 | MEN1 (0.51) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL6608059 | 0.86 | MEN1 (0.39) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL6604719 | 0.84 | MEN1 (0.37) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL6604721 | 0.84 | MEN1 (0.37) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL6603719 | 0.83 | NCEH1 (0.40) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL6608246 | 0.78 | KDM4E (0.42) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL4031840 | 0.78 | KDM4E (0.39) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL4656172 | 0.75 | HPGD (0.43) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL6608065 | 0.75 | KDM4E (0.39) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL6602935 | 0.75 | ALDH1A1 (0.39) | MEN1KMT2AKDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119551-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1433783-A2 | Naphthalenecarboxamides as tachykinin receptor antagonists | AstraZeneca AB (SE) | 2004-06-30 | — | — | EP | disclosed |
| EP-1119551-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020389-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-04-13 | — | — | WO | disclosed |