Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | ME2 | P23368 | 1/20 | 0.36 |
| ▸ | ME1 | P48163 | 1/20 | 0.36 |
| ▸ | ME3 | Q16798 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6605872 | 0.87 | MEN1 (0.39) | MEN1KMT2ACYP1A2KDM4EALDH1A1 | |
| SCHEMBL6603719 | 0.84 | NCEH1 (0.40) | MEN1KMT2ACYP1A2KDM4EALDH1A1 | |
| SCHEMBL6602894 | 0.83 | MEN1 (0.49) | MEN1KMT2ACYP1A2KDM4EALDH1A1 | |
| SCHEMBL6602899 | 0.83 | MEN1 (0.49) | MEN1KMT2ACYP1A2KDM4EALDH1A1 | |
| SCHEMBL16146645 | 0.79 | MEN1 (0.58) | MEN1KMT2ACYP1A2KDM4EALDH1A1 | |
| SCHEMBL27541400 | 0.79 | KDM4E (0.58) | MEN1KMT2ACYP1A2KDM4EALDH1A1 | |
| SCHEMBL6545857 | 0.79 | MEN1 (0.58) | MEN1KMT2ACYP1A2KDM4EALDH1A1 | |
| SCHEMBL6517134 | 0.78 | KMT2A (0.56) | MEN1KMT2ACYP1A2KDM4EALDH1A1 | |
| SCHEMBL4657181 | 0.77 | ALDH1A1 (0.51) | MEN1KMT2ACYP1A2KDM4EALDH1A1 | |
| SCHEMBL4656053 | 0.74 | KDM4E (0.51) | MEN1KMT2ACYP1A2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119551-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1433783-A2 | Naphthalenecarboxamides as tachykinin receptor antagonists | AstraZeneca AB (SE) | 2004-06-30 | — | — | EP | disclosed |
| EP-1119551-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020389-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-04-13 | — | — | WO | disclosed |