Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.66 |
| ▸ | GSK3B | P49841 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CLTC | Q00610 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3031538 | 0.81 | GSK3A (0.66) | GSK3AGSK3BKMT2ACYP11B1CYP11B2 | |
| SCHEMBL5182321 | 0.81 | GSK3A (0.66) | GSK3AGSK3BKMT2ATNKSHTR1D | |
| SCHEMBL30361151 | 0.81 | GSK3A (0.66) | GSK3AGSK3BKMT2ACYP11B1CYP11B2 | |
| SCHEMBL5311390 | 0.80 | GSK3A (0.69) | GSK3AGSK3BKMT2ACYP11B1CYP11B2 | |
| SCHEMBL6607455 | 0.80 | CA12 (0.47) | KMT2ACYP11B1CYP11B2MEN1CLTC | |
| SCHEMBL3318940 | 0.80 | GSK3A (1.00) | GSK3AGSK3BKMT2AMEN1GAA | |
| SCHEMBL15651790 | 0.79 | GSK3A (0.62) | GSK3AGSK3BKMT2ATNKSHTR1D | |
| SCHEMBL3140635 | 0.78 | GSK3A (0.60) | GSK3AGSK3BKMT2ATNKSHTR1D | |
| SCHEMBL8079266 | 0.75 | GSK3A (0.66) | GSK3AGSK3BKMT2AHTR1DHTR1B | |
| SCHEMBL20804240 | 0.75 | MGLL (0.60) | GSK3AGSK3BCYP11B1CYP11B2CLTC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436269-A1 | OXADIAZOLYL-BIPHENYLCARBOXAMIDES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003033482-A1 | OXADIAZOLYL-BIPHENYLCARBOXAMIDES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |