Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.43 |
| ▸ | CLTC | Q00610 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3292597 | 0.81 | CA12 (0.44) | CA12CA1CA2CA9POLB | |
| SCHEMBL6605903 | 0.80 | GSK3A (0.66) | CYP11B1CYP11B2MAOAMAOBMEN1 | |
| SCHEMBL20804240 | 0.80 | MGLL (0.60) | CYP11B1CYP11B2MAOAMAOBABHD6 | |
| SCHEMBL5782807 | 0.79 | GSK3A (0.67) | POLBCYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL28555863 | 0.79 | CYP2C9 (0.65) | MEN1KMT2ACYP1A2GAACYP2C9 | |
| SCHEMBL20804319 | 0.79 | ALDH1A1 (0.58) | POLBMEN1KMT2AALDH1A1HTT | |
| SCHEMBL5766288 | 0.79 | SMN1; SMN2 (0.53) | CA12CA1CA2CA9POLB | |
| Hydrochloric Acid SCHEMBL5460366 | 0.78 | GSK3A (0.65) | POLBMAOAMAOBMEN1KMT2A | |
| SCHEMBL2025369 | 0.77 | KMT2A (0.60) | CA12CA1CA2CA9POLB | |
| SCHEMBL7217564 | 0.77 | CA1 (0.62) | CA12CA1CA2CA9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436269-A1 | OXADIAZOLYL-BIPHENYLCARBOXAMIDES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003033482-A1 | OXADIAZOLYL-BIPHENYLCARBOXAMIDES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |