Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.60 |
| ▸ | IKBKB | O14920 | 7/20 | 0.58 |
| ▸ | GSK3B | P49841 | 3/20 | 0.58 |
| ▸ | DKK1 | O94907 | 2/20 | 0.58 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.58 |
| ▸ | CDK1 | P06493 | 5/20 | 0.58 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.58 |
| ▸ | CDK9 | P50750 | 5/20 | 0.58 |
| ▸ | CDK4 | P11802 | 5/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.58 |
| ▸ | CDK7 | P50613 | 2/20 | 0.58 |
| ▸ | CCNH | P51946 | 2/20 | 0.58 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.58 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.58 |
| ▸ | CCND1 | P24385 | 1/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.58 |
| ▸ | CCND3 | P30281 | 1/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.58 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4822550 | 0.85 | CDK2 (0.63) | CDK2IKBKBGSK3BDKK1CCNT1 | |
| SCHEMBL6601934 | 0.83 | CCNT1 (0.61) | CDK2IKBKBGSK3BDKK1CCNT1 | |
| SCHEMBL22650623 | 0.79 | CDK2 (0.52) | CDK2IKBKBGSK3BDKK1CCNT1 | |
| SCHEMBL6593928 | 0.75 | CDK2 (0.69) | CDK2IKBKBGSK3BDKK1CCNT1 | |
| SCHEMBL6104395 | 0.75 | CDK2 (1.00) | CDK2IKBKBGSK3BDKK1CCNT1 | |
| SCHEMBL3518049 | 0.75 | IKBKB (0.79) | CDK2IKBKBGSK3BDKK1CDK4 | |
| SCHEMBL3517290 | 0.74 | IKBKB (0.78) | CDK2IKBKBGSK3BDKK1CCNT1 | |
| SCHEMBL4826639 | 0.74 | CDK2 (0.57) | CDK2GSK3BCCNT1CDK1CCNB1 | |
| SCHEMBL11264019 | 0.74 | IKBKB (0.66) | CDK2IKBKBGSK3BDKK1CCNT1 | |
| Azd-5438 SCHEMBL29388208 | 0.73 | CDK2 (1.00) | CDK2GSK3BCCNT1CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485374-A1 | PYRIMIDINE COMPOUNDS | AstraZeneca AB (SE) | 2004-12-15 | — | — | EP | claimed |
| WO-2003076433-A1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-09-18 | — | — | WO | claimed |