Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NMT2 | O60551 | 2/20 | 0.40 |
| ▸ | NMT1 | P30419 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601172 | 0.81 | CYP2D6 (0.42) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPT | |
| SCHEMBL28797295 | 0.78 | KDM4E (0.53) | KMT2ASMN1; SMN2MEN1LMNAKDM4E | |
| SCHEMBL14238204 | 0.75 | SMN1; SMN2 (0.55) | KMT2ASMN1; SMN2MEN1LMNAKDM4E | |
| SCHEMBL27659536 | 0.75 | SMN1; SMN2 (0.58) | KMT2ASMN1; SMN2MEN1LMNAKDM4E | |
| SCHEMBL29860485 | 0.75 | SMN1; SMN2 (0.58) | KMT2ASMN1; SMN2MEN1LMNAKDM4E | |
| SCHEMBL538291 | 0.75 | SMN1; SMN2 (0.69) | KMT2ASMN1; SMN2MEN1LMNAKDM4E | |
| SCHEMBL27327783 | 0.73 | KDM4E (0.57) | KMT2ASMN1; SMN2MEN1LMNAKDM4E | |
| SCHEMBL28126276 | 0.73 | SMN1; SMN2 (0.55) | KMT2ASMN1; SMN2MEN1LMNAKDM4E | |
| SCHEMBL11075264 | 0.73 | KDM4E (0.61) | KMT2ASMN1; SMN2MEN1LMNAKDM4E | |
| SCHEMBL27276256 | 0.73 | SMN1; SMN2 (0.55) | KMT2ASMN1; SMN2MEN1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412349-A2 | PIPERAZINE OXYQUINOLINE (NAPHTHALINE) PLATELET ADENOSINE DIPHOSPHATE RECEPTOR ANTAGONISTS | Schering Aktiengesellschaft (DE) | 2004-04-28 | — | — | EP | disclosed |
| WO-2002098856-A2 | PIPERAZINE OXYQUINOLINE (NAPHTHALINE) PLATELET ADENOSINE DIPHOSPHATE RECEPTOR ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-12-12 | — | — | WO | disclosed |