Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 14/20 | 0.46 |
| ▸ | BRAF | P15056 | 9/20 | 0.44 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.43 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615991 | 0.94 | NPSR1 (0.46) | NPSR1RAF1BRAFADCY8ADCY1 | |
| SCHEMBL6616122 | 0.90 | RAF1 (0.46) | RAF1BRAFADCY8ADCY1POLB | |
| SCHEMBL6617382 | 0.86 | RAF1 (0.42) | RAF1BRAFADCY8ADCY1POLB | |
| SCHEMBL6615338 | 0.85 | RAF1 (0.44) | RAF1BRAFPOLBCTDSP1MEN1 | |
| SCHEMBL6615137 | 0.85 | RAF1 (0.41) | RAF1BRAFADCY8ADCY1POLB | |
| SCHEMBL6620165 | 0.85 | RAF1 (0.44) | RAF1BRAFPOLBCTDSP1 | |
| SCHEMBL6617712 | 0.84 | RAF1 (0.44) | RAF1BRAFPOLBMEN1KMT2A | |
| SCHEMBL6619006 | 0.84 | CRACR2A (0.46) | POLBMEN1KMT2A | |
| SCHEMBL6617441 | 0.84 | RAF1 (0.45) | RAF1BRAF | |
| SCHEMBL6672260 | 0.84 | MEN1 (0.45) | RAF1BRAFMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | disclosed |