Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 13/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 10/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672260 | 0.94 | MEN1 (0.45) | RAF1BRAFMEN1HTTRAB9A | |
| SCHEMBL6620165 | 0.94 | RAF1 (0.44) | RAF1POLBBRAFLMNAKCNK3 | |
| SCHEMBL6615137 | 0.92 | RAF1 (0.41) | RAF1POLBBRAFCCR2 | |
| SCHEMBL6617441 | 0.89 | RAF1 (0.45) | RAF1BRAFCCR2 | |
| SCHEMBL6614038 | 0.89 | KCNK3 (0.44) | RAF1POLBBRAFLMNARAB9A | |
| SCHEMBL6685899 | 0.89 | RAF1 (0.42) | RAF1POLBBRAFKCNK3 | |
| SCHEMBL6619787 | 0.89 | MAPK14 (0.41) | POLBLMNAMAPTMEN1RAB9A | |
| SCHEMBL6616122 | 0.88 | RAF1 (0.46) | RAF1POLBBRAF | |
| SCHEMBL6614784 | 0.87 | POLB (0.41) | POLBMAPT | |
| SCHEMBL6618645 | 0.86 | TP53 (0.49) | RAF1POLBBRAFLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |