Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.45 |
| ▸ | DDT | P30046 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 14/20 | 0.44 |
| ▸ | BRAF | P15056 | 11/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617712 | 0.94 | RAF1 (0.44) | MEN1HTTRAB9AKMT2AKCNK3 | |
| SCHEMBL6620165 | 0.93 | RAF1 (0.44) | KCNK3RAF1BRAF | |
| SCHEMBL6616425 | 0.89 | NAMPT (0.40) | MEN1RAB9AKMT2ADDT | |
| SCHEMBL6617441 | 0.89 | RAF1 (0.45) | RAF1BRAFCCR2 | |
| SCHEMBL6615137 | 0.89 | RAF1 (0.41) | RAF1BRAFCCR2 | |
| SCHEMBL6614038 | 0.88 | KCNK3 (0.44) | RAB9AKCNK3RAF1BRAFCCR2 | |
| SCHEMBL6685899 | 0.88 | RAF1 (0.42) | KCNK3RAF1BRAF | |
| SCHEMBL6616122 | 0.88 | RAF1 (0.46) | RAF1BRAF | |
| SCHEMBL6619971 | 0.87 | RAF1 (0.43) | KCNK3RAF1BRAF | |
| SCHEMBL6677022 | 0.86 | NAMPT (0.45) | MEN1RAB9AKMT2AKCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |