SCHEMBL6606923

SCHEMBL6606923

COc1cccc(-c2ccccc2)c1F

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 1/20 0.51
BACE1 P56817 1/20 0.48
ALDH1A1 P00352 3/20 0.47
NPC1 O15118 3/20 0.47
RAB9A P51151 3/20 0.47
SMN1; SMN2 Q16637 3/20 0.47
TP53 P04637 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA4 P22748 1/20 0.46
CA7 P43166 1/20 0.46
CA9 Q16790 1/20 0.46
CA14 Q9ULX7 1/20 0.46
KDM4E B2RXH2 3/20 0.46
LMNA P02545 2/20 0.46
GAA P10253 1/20 0.46
DHODH Q02127 2/20 0.45
MAPT P10636 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17535975 0.88 ERN1 (0.51) ERN1BACE1CA12CA1CA2
SCHEMBL19770515 0.87 FGFR1 (0.44) ERN1BACE1ALDH1A1NPC1RAB9A
SCHEMBL10093046 0.85 ERN1 (0.49) ERN1BACE1ALDH1A1NPC1RAB9A
SCHEMBL13262855 0.84 CYP3A4 (0.42) ERN1ALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL28189326 0.82 CYP1A2 (0.54) ERN1BACE1ALDH1A1L3MBTL1LMNA
SCHEMBL30136447 0.81 ALDH1A1 (0.58) ALDH1A1NPC1RAB9ASMN1; SMN2TP53
SCHEMBL294721 0.81 ALDH1A1 (0.58) ALDH1A1NPC1RAB9ASMN1; SMN2TP53
SCHEMBL29997377 0.79 FGFR1 (0.53) ALDH1A1RAB9ATP53L3MBTL1KDM4E
SCHEMBL28826439 0.79 HTR1A (0.42) ALDH1A1CA1CA2CA7CA9
SCHEMBL28891200 0.79 FGFR1 (0.53) ALDH1A1RAB9ATP53L3MBTL1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105143216-A Antibacterial biaromatic derivatives ACTELION PHARMACEUTICALS LTD 2015-12-09 CN claimed
EP-1034164-B1 SUBSTITUTED BETA-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS MERCK & CO INC (US) 2004-05-19 EP claimed
EP-1034164-A4 SUBSTITUTED BETA-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS MERCK & CO INC (US) 2001-07-11 EP claimed
EP-1034164-A1 SUBSTITUTED BETA-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS Merck & Co., Inc. (US) 2000-09-13 EP claimed
WO-1999026921-A1 SUBSTITUTED β-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS MERCK & CO., INC. (US) 1999-06-03 WO claimed
CN-105143216-A Antibacterial biaromatic derivatives ACTELION PHARMACEUTICALS LTD 2015-12-09 CN disclosed
CN-104326952-A METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF SUMITOMO CHEMICAL CO 2015-02-04 CN disclosed
CN-104277004-A METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF SUMITOMO CHEMICAL CO 2015-01-14 CN disclosed
CN-103965133-A N, S heterocycle-containing compound having DHODH inhibition activity, preparation and use thereof UNIV EAST CHINA SCIENCE & TECH 2014-08-06 CN disclosed
CN-103965134-A N, S-containing heterocyclic compound with nematicidal activity, preparation method and application thereof UNIV EAST CHINA SCIENCE & TECH 2014-08-06 CN disclosed
CN-103180300-A Process for producing pyridazinone compound and intermediate thereof SUMITOMO CHEMICAL CO 2013-06-26 CN disclosed
EP-1034164-B1 SUBSTITUTED BETA-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS MERCK & CO INC (US) 2004-05-19 EP disclosed
US-6645939-B1 Very late antigen-4 (VLA) integrin antagonists; antiallergens, antiasthmatics, and antiinflammatory agents; multiple sclerosis, autoimmune disease treatment MERCK & CO., INC. 2003-11-11 US disclosed
EP-1034164-A4 SUBSTITUTED BETA-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS MERCK & CO INC (US) 2001-07-11 EP disclosed
WO-2000071572-A1 SUBSTITUTED BETA-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS MERCK & CO., INC. (US) 2000-11-30 WO disclosed
EP-1034164-A1 SUBSTITUTED BETA-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS Merck & Co., Inc. (US) 2000-09-13 EP disclosed
WO-1999026921-A1 SUBSTITUTED β-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS MERCK & CO., INC. (US) 1999-06-03 WO disclosed