Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6200011 | 0.88 | KCNH2 (0.53) | POLA1KCNH2RXFP1F10MLLT1 | |
| SCHEMBL6770778 | 0.88 | KCNH2 (0.53) | POLA1KCNH2RXFP1F10MLLT1 | |
| SCHEMBL6726994 | 0.88 | KCNH2 (0.55) | POLA1KCNH2RXFP1F10MLLT1 | |
| SCHEMBL6727162 | 0.88 | KCNH2 (0.49) | POLA1KCNH2RXFP1F10ALDH1A1 | |
| SCHEMBL6201283 | 0.84 | KCNH2 (0.54) | POLA1KCNH2RXFP1F10MLLT1 | |
| SCHEMBL6733213 | 0.84 | ALDH1A1 (0.51) | POLA1KCNH2RXFP1ALDH1A1 | |
| SCHEMBL6200655 | 0.82 | KCNH2 (0.48) | POLA1KCNH2RXFP1F10MLLT1 | |
| SCHEMBL6202555 | 0.81 | RXFP1 (0.49) | POLA1KCNH2RXFP1MLLT1ALDH1A1 | |
| SCHEMBL6707995 | 0.81 | KCNH2 (0.61) | POLA1KCNH2RXFP1F10MLLT1 | |
| SCHEMBL6665763 | 0.81 | KCNH2 (0.54) | POLA1KCNH2RXFP1F10MLLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456208-A1 | PYRIDOQUINOXALINE ANTIVIRALS | PHARMACIA & UPJOHN COMPANY (US) | 2004-09-15 | — | — | EP | disclosed |
| US-20040106596-A1 | Pyridoquinoxaline antivirals | PERRAULT WILLIAM R (US) | 2004-06-03 | — | — | US | disclosed |
| US-6686356-B2 | HERPES VIRUS | PHARMACIA & UPJOHN COMPANY | 2004-02-03 | — | — | US | disclosed |
| US-20030130255-A1 | PYRIDOQUINOXALINE ANTIVIRALS | PHARMACIA & UPJOHN COMPANY | 2003-07-10 | — | — | US | disclosed |
| WO-2003053972-A1 | PYRIDOQUINOXALINE ANTIVIRALS | PHARMACIA & UPJOHN COMPANY (US) | 2003-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106596-A1 | Pyridoquinoxaline antivirals | IFNAR1, ZC3HAV1, SARS1 | POLA1 222/4885KCNH2 915/4885RXFP1 147/4885 |
| US-20030130255-A1 | PYRIDOQUINOXALINE ANTIVIRALS | IFNAR1, ZC3HAV1, SARS1 | POLA1 222/4885KCNH2 915/4885RXFP1 147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.