Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606983 | 1.00 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL4823570 | 0.83 | PDE4A (0.90) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL5194254 | 0.81 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DCES2 | |
| SCHEMBL5194266 | 0.81 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DCES2 | |
| SCHEMBL5194258 | 0.81 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DCES2 | |
| SCHEMBL11117845 | 0.80 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL11117847 | 0.80 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL11290195 | 0.80 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL4825120 | 0.79 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL4825122 | 0.79 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444010-A2 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003037886-A2 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2003-05-08 | — | — | WO | disclosed |