Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TCF4 | P15884 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5194254 | 1.00 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL5194266 | 1.00 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL4619766 | 0.81 | PDE4A (0.86) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL16413553 | 0.81 | NQO1 (0.47) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL16413554 | 0.81 | NQO1 (0.47) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL16413555 | 0.81 | NQO1 (0.47) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL6606982 | 0.81 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL6606983 | 0.81 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL10667909 | 0.79 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL10677326 | 0.79 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9925193-B2 | Thioether derivatives as protein kinase inhibitors | PROQINASE GMBH (DE) | 2018-03-27 | — | — | US | disclosed |
| US-9688653-B2 | Ethoxyphenyl thienyl compounds and methods for the treatment of bacterial infections | DUKE UNIVERSITY (US) | 2017-06-27 | — | — | US | disclosed |
| US-9688653-B2 | Ethoxyphenyl thienyl compounds and methods for the treatment of bacterial infections | DUKE UNIVERSITY (US) | 2017-06-27 | — | — | US | disclosed |
| US-20150328219-A1 | THIOETHER DERIVATIVES AS PROTEIN KINASE INHIBITORS | PROQINASE GMBH (DE) | 2015-11-19 | — | — | US | disclosed |
| US-20150031658-A1 | ETHOXYPHENYL THIENYL COMPOUNDS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS | UNIV DUKE (US) | 2015-01-29 | — | — | US | disclosed |
| US-20150031658-A1 | ETHOXYPHENYL THIENYL COMPOUNDS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS | UNIV DUKE (US) | 2015-01-29 | — | — | US | disclosed |
| WO-2014079545-A1 | THIOETHER DERIVATIVES AS PROTEIN KINASE INHIBITORS | KTB TUMORFORSCHUNGSGESELLSCHAFT MBH (DE) | 2014-05-30 | — | — | WO | disclosed |
| EP-2733146-A1 | Thioether derivatives as protein kinase inhibitors | KTB Tumorforschungsgesellschaft mbH (DE) | 2014-05-21 | — | — | EP | disclosed |
| US-20070249670-A1 | Glycogen Phosphorylase Inhibitor Compounds and Pharmaceutical Compositions Thereof | SMITHKLINE BEECHAM CORPORATION (US) | 2007-10-25 | — | — | US | disclosed |
| EP-1812383-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | Smithkline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006052722-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249670-A1 | Glycogen Phosphorylase Inhibitor Compounds and Pharmaceutical Compositions Thereof | PYGM, PYGL, GYS1 | PDE4A 234/4885PDE4B 263/4885PDE4C 294/4885 |
| US-20150031658-A1 | ETHOXYPHENYL THIENYL COMPOUNDS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS | GGPS1, FDPS, FNTA | PDE4A 1345/4885PDE4B 1486/4885PDE4C 1055/4885 |
| US-20150328219-A1 | THIOETHER DERIVATIVES AS PROTEIN KINASE INHIBITORS | MAP3K1, MAP3K6, MAP3K20 | PDE4A 2257/4885PDE4B 3033/4885PDE4C 3050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.