SCHEMBL6607048

SCHEMBL6607048

O=C(Nc1ccc(CC(=O)N2CCCC(c3ccc4c(c3)OCO4)=N2)cc1)c1cccnc1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 7/20 0.52
RAB9A P51151 7/20 0.52
TP53 P04637 5/20 0.52
SMN1; SMN2 Q16637 5/20 0.52
ALDH1A1 P00352 4/20 0.52
HPGD P15428 3/20 0.50
MAPT P10636 3/20 0.45
KDM4E B2RXH2 2/20 0.45
TDP1 Q9NUW8 2/20 0.45
ESR1 P03372 1/20 0.45
HSD17B10 Q99714 1/20 0.45
POLB P06746 1/20 0.44
AHR P35869 1/20 0.44
AGBL2 Q5U5Z8 1/20 0.44
MAPK1 P28482 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
GFER P55789 1/20 0.43
FAAH O00519 1/20 0.43
NAMPT P43490 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL145733 0.88 ALDH1A1 (0.56) NPC1RAB9ATP53SMN1; SMN2ALDH1A1
SCHEMBL7650105 0.86 SMN1; SMN2 (0.42) NPC1RAB9ATP53SMN1; SMN2ALDH1A1
SCHEMBL6601945 0.85 ABCG2 (0.53) NPC1RAB9ATP53SMN1; SMN2ALDH1A1
Hydrochloric Acid SCHEMBL7650717 0.84 ABCG2 (0.53) NPC1RAB9ATP53SMN1; SMN2ALDH1A1
SCHEMBL6602631 0.81 ABCG2 (0.48) NPC1RAB9ASMN1; SMN2ALDH1A1MAPT
SCHEMBL6601996 0.81 ABCG2 (0.48) NPC1RAB9ATP53SMN1; SMN2ALDH1A1
SCHEMBL6606959 0.80 ABCG2 (0.47) NPC1RAB9ASMN1; SMN2ALDH1A1MAPT
SCHEMBL6601874 0.80 ABCG2 (0.47) NPC1RAB9ATP53SMN1; SMN2ALDH1A1
SCHEMBL6602802 0.78 MCHR1 (0.40) NPC1RAB9AALDH1A1POLB
SCHEMBL6600744 0.77 AHR (0.61) NPC1RAB9ATP53SMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0922036-B1 ARYLALKANOYL PYRIDAZINES MERCK PATENT GMBH (DE) 2004-03-24 EP disclosed
US-6479494-B1 THEY INHIBIT SELECTIVELY PHOSPHODIESTERASE IV, WHICH CAUSES AN INCREASE OF THE INTRACELLULAR CAMP LEVEL AS CAMP INHIBITS BONE DECREASING CELLS AND STIMULATES BONE INCREASING CELLS FOR TREATMENT OF OSTEOPOROSIS MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 2002-11-12 US disclosed
US-6107295-A Arylalkanoyl pyridazines MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2000-08-22 US disclosed