Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.42 |
| ▸ | NPC1 | O15118 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL145732 | 0.89 | SMN1; SMN2 (0.44) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL6607048 | 0.86 | NPC1 (0.52) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL6601945 | 0.83 | ABCG2 (0.53) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL7650717 | 0.82 | ABCG2 (0.53) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL7649465 | 0.80 | PGR (0.38) | SMN1; SMN2RAB9AMAPTALDH1A1L3MBTL1 | |
| SCHEMBL6602631 | 0.79 | ABCG2 (0.48) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL6601996 | 0.79 | ABCG2 (0.48) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL7651110 | 0.79 | PGR (0.45) | SMN1; SMN2RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL6606959 | 0.78 | ABCG2 (0.47) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL6601874 | 0.78 | ABCG2 (0.47) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479494-B1 | THEY INHIBIT SELECTIVELY PHOSPHODIESTERASE IV, WHICH CAUSES AN INCREASE OF THE INTRACELLULAR CAMP LEVEL AS CAMP INHIBITS BONE DECREASING CELLS AND STIMULATES BONE INCREASING CELLS FOR TREATMENT OF OSTEOPOROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-11-12 | — | — | US | disclosed |
| US-6107295-A | Arylalkanoyl pyridazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-22 | — | — | US | disclosed |