SCHEMBL6607551

SCHEMBL6607551

CN1CCc2c(-c3ccccc3)cc3c(c2C1)NC(=O)C3=NOCC(=O)OC(C)(C)C

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DDB1 Q16531 1/20 0.34
CRBN Q96SW2 1/20 0.34
UCHL1 P09936 3/20 0.33
MAPT P10636 5/20 0.33
USP30 Q70CQ3 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
LMNA P02545 1/20 0.33
POLB P06746 1/20 0.33
CYP2C9 P11712 1/20 0.33
HPGD P15428 1/20 0.33
CYP2C19 P33261 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
BACE1 P56817 3/20 0.32
MTNR1A P48039 1/20 0.32
MTNR1B P49286 1/20 0.32
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
RAB9A P51151 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6607248 0.89 MAPK8 (0.33) MAPTSMN1; SMN2POLBCYP2C9HPGD
SCHEMBL6607506 0.89 MAPK8 (0.38) MAPTSMN1; SMN2LMNAPOLBHPGD
SCHEMBL6610333 0.88 MAPT (0.34) MAPTSMN1; SMN2POLBCYP2C9CYP2C19
SCHEMBL6610032 0.86 POLB (0.33) MAPTSMN1; SMN2POLBHPGDKDM4E
SCHEMBL6612550 0.86 ALDH1A1 (0.34) MAPTSMN1; SMN2LMNAPOLBHPGD
SCHEMBL6608156 0.85 ALDH1A1 (0.39) MAPTSMN1; SMN2LMNAHPGDCYP2C19
SCHEMBL6607469 0.84 POLB (0.30) MAPTSMN1; SMN2POLBKDM4EALDH1A1
SCHEMBL6607521 0.83 MAPT (0.33) UCHL1MAPTUSP30SMN1; SMN2CYP2C9
Hydrochloric Acid SCHEMBL6608203 0.82 SLC2A1 (0.33) UCHL1MAPTUSP30SMN1; SMN2CYP2C9
SCHEMBL4363227 0.82 MAPT (0.34) MAPTSMN1; SMN2LMNAPOLBCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869958-B1 NOVEL INDOLE-2,3-DIONE-3-OXIME DERIVATIVES NEUROSEARCH AS (DK) 2004-12-29 EP claimed
EP-1066037-B1 USE OF INDOLE-2,3-DIONE-3-OXIME DERIVATIVES AS AMPA ANTAGONISTS NEUROSEARCH AS (DK) 2004-12-29 EP claimed
US-RE38200-E1 Capable of antagonizing effect of excitatory amino acids, such as glutamate NEUROSEARCH A/S (DK) 2003-07-22 US claimed
US-6239128-B1 COMBATING DISEASES AND DISORDERS ASSOCIATED WITH OR MEDIATED BY THE RELEASE OF EXCITATORY AMINO ACIDS, ASSOCIATED WITH REDUCED BLOOD FLOW TO THE BRAIN AND OTHER CNS TISSUE, NEUROSEARCH A/S (DK) 2001-05-29 US claimed
US-6124285-A Indole-2,3-dione-3-oxime derivatives NEUROSEARCH A/S (DK) 2000-09-26 US claimed
EP-0869958-B1 NOVEL INDOLE-2,3-DIONE-3-OXIME DERIVATIVES NEUROSEARCH AS (DK) 2004-12-29 EP disclosed
EP-1066037-B1 USE OF INDOLE-2,3-DIONE-3-OXIME DERIVATIVES AS AMPA ANTAGONISTS NEUROSEARCH AS (DK) 2004-12-29 EP disclosed
US-6693111-B1 1H-PYRROLO(3,2-H)ISOQUINOLINE DERIVATIVES; EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS NEUROSEARCH A/S (DK) 2004-02-17 US disclosed
US-RE38200-E1 Capable of antagonizing effect of excitatory amino acids, such as glutamate NEUROSEARCH A/S (DK) 2003-07-22 US disclosed
US-6239128-B1 COMBATING DISEASES AND DISORDERS ASSOCIATED WITH OR MEDIATED BY THE RELEASE OF EXCITATORY AMINO ACIDS, ASSOCIATED WITH REDUCED BLOOD FLOW TO THE BRAIN AND OTHER CNS TISSUE, NEUROSEARCH A/S (DK) 2001-05-29 US disclosed
US-6124285-A Indole-2,3-dione-3-oxime derivatives NEUROSEARCH A/S (DK) 2000-09-26 US disclosed