SCHEMBL6607248

SCHEMBL6607248

CN1CCc2c(-c3ccccc3)cc3c(c2C1)NC(=O)C3=NOCC(=O)O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK8 P45983 1/20 0.33
MAPK9 P45984 1/20 0.33
MAPK10 P53779 1/20 0.33
MAPT P10636 4/20 0.33
TP53 P04637 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
GRIA1 P42261 1/20 0.33
GRIA2 P42262 1/20 0.33
GRIA3 P42263 1/20 0.33
GRIA4 P48058 1/20 0.33
CHRM5 P08912 3/20 0.32
CHRM1 P11229 3/20 0.32
HTR1A P08908 1/20 0.32
ADRA1D P25100 1/20 0.32
HTR1B P28222 1/20 0.32
ADRA1A P35348 1/20 0.32
ADRA1B P35368 1/20 0.32
GAA P10253 2/20 0.32
POLB P06746 2/20 0.32
SLC2A1 P11166 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6612550 0.91 ALDH1A1 (0.34) MAPTTP53SMN1; SMN2GRIA1GRIA2
SCHEMBL6610032 0.91 POLB (0.33) MAPTTP53SMN1; SMN2GRIA1GRIA2
SCHEMBL6607506 0.90 MAPK8 (0.38) MAPK8MAPK9MAPK10MAPTSMN1; SMN2
SCHEMBL6607551 0.89 DDB1 (0.34) MAPTTP53SMN1; SMN2HTR1AADRA1D
SCHEMBL6608156 0.89 ALDH1A1 (0.39) MAPTSMN1; SMN2SLC2A1ALDH1A1KDM4E
SCHEMBL6610333 0.89 MAPT (0.34) MAPTTP53SMN1; SMN2GRIA1GRIA2
SCHEMBL6607469 0.89 POLB (0.30) MAPTTP53SMN1; SMN2GRIA1GRIA2
SCHEMBL6607933 0.88 HTR6 (0.38) MAPTTP53GRIA1GRIA2GRIA3
Hydrochloric Acid SCHEMBL6607627 0.87 HTR6 (0.37) MAPTGRIA1GRIA2GRIA3GRIA4
SCHEMBL4363227 0.87 MAPT (0.34) MAPTTP53SMN1; SMN2GRIA1GRIA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869958-B1 NOVEL INDOLE-2,3-DIONE-3-OXIME DERIVATIVES NEUROSEARCH AS (DK) 2004-12-29 EP claimed
EP-1066037-B1 USE OF INDOLE-2,3-DIONE-3-OXIME DERIVATIVES AS AMPA ANTAGONISTS NEUROSEARCH AS (DK) 2004-12-29 EP claimed
US-RE38200-E1 Capable of antagonizing effect of excitatory amino acids, such as glutamate NEUROSEARCH A/S (DK) 2003-07-22 US claimed
US-6239128-B1 COMBATING DISEASES AND DISORDERS ASSOCIATED WITH OR MEDIATED BY THE RELEASE OF EXCITATORY AMINO ACIDS, ASSOCIATED WITH REDUCED BLOOD FLOW TO THE BRAIN AND OTHER CNS TISSUE, NEUROSEARCH A/S (DK) 2001-05-29 US claimed
US-6124285-A Indole-2,3-dione-3-oxime derivatives NEUROSEARCH A/S (DK) 2000-09-26 US claimed
EP-0869958-B1 NOVEL INDOLE-2,3-DIONE-3-OXIME DERIVATIVES NEUROSEARCH AS (DK) 2004-12-29 EP disclosed
EP-1066037-B1 USE OF INDOLE-2,3-DIONE-3-OXIME DERIVATIVES AS AMPA ANTAGONISTS NEUROSEARCH AS (DK) 2004-12-29 EP disclosed
US-6693111-B1 1H-PYRROLO(3,2-H)ISOQUINOLINE DERIVATIVES; EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS NEUROSEARCH A/S (DK) 2004-02-17 US disclosed
US-RE38200-E1 Capable of antagonizing effect of excitatory amino acids, such as glutamate NEUROSEARCH A/S (DK) 2003-07-22 US disclosed
US-6239128-B1 COMBATING DISEASES AND DISORDERS ASSOCIATED WITH OR MEDIATED BY THE RELEASE OF EXCITATORY AMINO ACIDS, ASSOCIATED WITH REDUCED BLOOD FLOW TO THE BRAIN AND OTHER CNS TISSUE, NEUROSEARCH A/S (DK) 2001-05-29 US disclosed
EP-1066037-A1 INDOLE-2,3-DIONE-3-OXIME DERIVATIVES FOR THERAPEUTIC USE NEUROSEARCH A/S (DK) 2001-01-10 EP disclosed
US-6124285-A Indole-2,3-dione-3-oxime derivatives NEUROSEARCH A/S (DK) 2000-09-26 US disclosed
WO-1999049864-A1 INDOLE-2,3-DIONE-3-OXIME DERIVATIVES FOR THERAPEUTIC USE NEUROSEARCH A/S (DK) 1999-10-07 WO disclosed