Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | DHODH | Q02127 | 2/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603724 | 0.84 | ALDH1A1 (0.39) | ALDH1A1MAPK1STAT3PDE10AKDM4E | |
| SCHEMBL6604100 | 0.81 | PDE10A (0.47) | ALDH1A1MAPK1STAT3PDE10AKDM4E | |
| SCHEMBL6605190 | 0.78 | KDM4E (0.47) | ALDH1A1MAPK1STAT3PDE10AKDM4E | |
| SCHEMBL6602795 | 0.74 | ALDH1A1 (0.40) | ALDH1A1MAPK1STAT3PDE10AKDM4E | |
| SCHEMBL6603196 | 0.74 | ALDH1A1 (0.46) | ALDH1A1MAPK1STAT3PDE10AKDM4E | |
| SCHEMBL6602894 | 0.74 | MEN1 (0.49) | ALDH1A1KDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL6602899 | 0.74 | MEN1 (0.49) | ALDH1A1KDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL6604603 | 0.73 | ALDH1A1 (0.42) | ALDH1A1MAPK1STAT3PDE10AKDM4E | |
| SCHEMBL6608036 | 0.71 | ALDH1A1 (0.43) | ALDH1A1MAPK1STAT3PDE10AKDM4E | |
| SCHEMBL655431 | 0.71 | PDE10A (0.57) | ALDH1A1PDE10AKDM4ETSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119551-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1433783-A2 | Naphthalenecarboxamides as tachykinin receptor antagonists | AstraZeneca AB (SE) | 2004-06-30 | — | — | EP | disclosed |
| EP-1119551-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020389-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-04-13 | — | — | WO | disclosed |