Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | IGF1R | P08069 | 2/20 | 0.46 |
| ▸ | IGF2R | P11717 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.44 |
| ▸ | PDE4A | P27815 | 5/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6607790 | 1.00 | EGFR (0.46) | EGFRIGF1RIGF2RMAPTMEN1 | |
| SCHEMBL6609089 | 0.92 | MAPT (0.46) | EGFRIGF1RIGF2RMAPTMEN1 | |
| SCHEMBL6609083 | 0.92 | MAPT (0.46) | EGFRIGF1RIGF2RMAPTMEN1 | |
| SCHEMBL6611396 | 0.88 | MAPT (0.46) | EGFRIGF1RIGF2RMAPTMEN1 | |
| SCHEMBL6611390 | 0.88 | MAPT (0.46) | EGFRIGF1RIGF2RMAPTMEN1 | |
| SCHEMBL6611309 | 0.86 | EGFR (0.45) | EGFRIGF1RIGF2RMAPTMEN1 | |
| SCHEMBL6611313 | 0.86 | EGFR (0.45) | EGFRIGF1RIGF2RMAPTMEN1 | |
| SCHEMBL6607238 | 0.85 | PDE4A (0.40) | EGFRIGF1RIGF2RMAPTMEN1 | |
| SCHEMBL6607249 | 0.85 | PDE4A (0.40) | EGFRIGF1RIGF2RMAPTMEN1 | |
| SCHEMBL6606002 | 0.81 | MAPT (0.41) | EGFRIGF1RIGF2RMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882714-B1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS PHARMACEUTICAL CO (JP) | 2004-03-03 | — | — | EP | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |