Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | IGF2R | P11717 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609089 | 1.00 | MAPT (0.46) | MAPTKDM4EALDH1A1EGFRSMN1; SMN2 | |
| SCHEMBL6607790 | 0.92 | EGFR (0.46) | MAPTKDM4EALDH1A1EGFRSMN1; SMN2 | |
| SCHEMBL6607800 | 0.92 | EGFR (0.46) | MAPTKDM4EALDH1A1EGFRSMN1; SMN2 | |
| SCHEMBL6611390 | 0.87 | MAPT (0.46) | MAPTKDM4EALDH1A1EGFRSMN1; SMN2 | |
| SCHEMBL6611396 | 0.87 | MAPT (0.46) | MAPTKDM4EALDH1A1EGFRSMN1; SMN2 | |
| SCHEMBL6610871 | 0.86 | MAPT (0.44) | MAPTKDM4EALDH1A1EGFRSMN1; SMN2 | |
| SCHEMBL6610876 | 0.86 | MAPT (0.44) | MAPTKDM4EALDH1A1EGFRSMN1; SMN2 | |
| SCHEMBL6609189 | 0.85 | MAPT (0.43) | MAPTKDM4EALDH1A1EGFRSMN1; SMN2 | |
| SCHEMBL6609196 | 0.85 | MAPT (0.43) | MAPTKDM4EALDH1A1EGFRSMN1; SMN2 | |
| SCHEMBL6606002 | 0.81 | MAPT (0.41) | MAPTKDM4EALDH1A1EGFRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882714-B1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS PHARMACEUTICAL CO (JP) | 2004-03-03 | — | — | EP | disclosed |
| US-5935977-A | PHOSPHODIESTERASE IV INHIBITORS, TUMOR NECROSIS FACTOR-ALPHA PRODUCTION INHIBITORS; TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |