Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6610982 | 0.88 | TAS1R3 (0.39) | ALDH1A1EIF2AK4ALOX5 | |
| SCHEMBL6319630 | 0.88 | ALDH1A1 (0.41) | ALDH1A1MAPTMAPK1POLBMAPK14 | |
| SCHEMBL4452237 | 0.84 | ALDH1A1 (0.43) | ALDH1A1MAPTMAPK1POLBMAPK14 | |
| Trifluoroacetic Acid SCHEMBL6321915 | 0.79 | MAPT (0.45) | ALDH1A1MAPTMAPK1POLBMAPK14 | |
| SCHEMBL5263394 | 0.78 | ALDH1A1 (0.39) | ALDH1A1MAPTMAPK1POLBMAPK14 | |
| SCHEMBL6314449 | 0.78 | HPGD (0.46) | ALDH1A1MAPTMAPK1MAPK14GAA | |
| SCHEMBL6312734 | 0.78 | NR4A3 (0.49) | ALDH1A1MAPTMAPK1POLBMAPK14 | |
| SCHEMBL7359681 | 0.78 | MALT1 (0.47) | MAPTGAA | |
| SCHEMBL4458512 | 0.77 | MALT1 (0.43) | LMNAEIF2AK4 | |
| Hydrochloric Acid SCHEMBL6313508 | 0.76 | MALT1 (0.42) | LMNAEIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056729-B1 | N-[(SUBSTITUTED FIVE-MEMBERED DI- OR TRIAZA DIUNSATURATED RING)CARBONYL]GUANIDINE DERIVATIVES FOR THE TREATMENT OF ISCHEMIA | PFIZER PROD INC (US) | 2004-12-29 | — | — | EP | disclosed |
| EP-1454902-A1 | N- (substituted five-membered di-or triaza diunsaturated ring)carbonyl guanidine derivateives for the treatment of ischemia | Pfizer Products Inc. (US) | 2004-09-08 | — | — | EP | disclosed |