Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 10/20 | 0.54 |
| ▸ | MMP9 | P14780 | 10/20 | 0.54 |
| ▸ | MMP13 | P45452 | 10/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 10/20 | 0.54 |
| ▸ | AVPR2 | P30518 | 7/20 | 0.44 |
| ▸ | AVPR1A | P37288 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | OXTR | P30559 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224797 | 0.90 | MMP1 (0.59) | MMP1MMP9MMP13ADAM17AVPR2 | |
| SCHEMBL6612895 | 0.90 | MMP1 (0.68) | MMP1MMP9MMP13ADAM17MAPT | |
| SCHEMBL6610148 | 0.84 | MMP13 (0.55) | MMP1MMP9MMP13ADAM17 | |
| SCHEMBL6609480 | 0.82 | MMP1 (0.69) | MMP1MMP9MMP13ADAM17MAPT | |
| SCHEMBL6609461 | 0.81 | MMP1 (0.61) | MMP1MMP9MMP13ADAM17MAPT | |
| SCHEMBL6612830 | 0.81 | MMP1 (0.53) | MMP1MMP9MMP13ADAM17MAPT | |
| SCHEMBL7424968 | 0.79 | MMP1 (0.63) | MMP1MMP9MMP13ADAM17MMP3 | |
| SCHEMBL6624052 | 0.79 | MMP1 (0.84) | MMP1MMP9MMP13ADAM17MAPT | |
| SCHEMBL6610535 | 0.79 | MMP1 (0.73) | MMP1MMP9MMP13ADAM17AVPR2 | |
| SCHEMBL6614379 | 0.79 | MMP1 (0.65) | MMP1MMP9MMP13ADAM17MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147095-B1 | 2, 3, 4, 5-TETRAHYDRO-1H-[1, 4] BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH CORP (US) | 2004-08-11 | — | — | EP | disclosed |