Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | EIF4EBP1 | Q13541 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164557 | 0.91 | USP30 (0.36) | CREBBPEP300PDE4DPDE7AMEN1 | |
| SCHEMBL6166434 | 0.89 | PDE7A (0.44) | CREBBPEP300PDE4DPDE7AMEN1 | |
| SCHEMBL6609371 | 0.83 | CREBBP (0.38) | CREBBPEP300PDE4DPDE7AMEN1 | |
| SCHEMBL6167957 | 0.81 | KDM4C (0.39) | KDM4CUSP30RXRA | |
| SCHEMBL6608414 | 0.81 | NTRK1 (0.33) | CREBBPEP300KMT2A | |
| SCHEMBL6634587 | 0.79 | GABRA5 (0.44) | CREBBPEP300MEN1KMT2A | |
| SCHEMBL6608326 | 0.79 | HDAC3 (0.42) | MEN1KMT2AS1PR1 | |
| SCHEMBL6168648 | 0.78 | RORC (0.31) | CREBBPEP300KMT2A | |
| SCHEMBL6610013 | 0.78 | MEN1 (0.41) | CREBBPEP300PDE4DPDE7AMEN1 | |
| SCHEMBL6612867 | 0.77 | NPC1 (0.39) | CREBBPEP300MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |