Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.33 |
| ▸ | PDE4A | P27815 | 5/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6605174 | 1.00 | CHEK1 (0.35) | CHEK1PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6611085 | 0.89 | PDE4D (0.43) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6611092 | 0.89 | PDE4D (0.43) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6609891 | 0.84 | PDE4D (0.44) | CHEK1PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6609898 | 0.84 | PDE4D (0.44) | CHEK1PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6606526 | 0.84 | PDE4B (0.42) | CHEK1PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6606520 | 0.84 | PDE4B (0.42) | CHEK1PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6610689 | 0.84 | CHEK1 (0.36) | CHEK1PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6609815 | 0.82 | PDE4A (0.46) | PDE4BPDE4DPDE4APDE4CALDH1A1 | |
| SCHEMBL6606787 | 0.80 | PDE4D (0.42) | PDE4BPDE4DPDE4APDE4CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882714-B1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS PHARMACEUTICAL CO (JP) | 2004-03-03 | — | — | EP | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |