Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 14/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.44 |
| ▸ | PDE4A | P27815 | 8/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609898 | 1.00 | PDE4D (0.44) | PDE4DPDE4BPDE4APDE4CCNR1 | |
| SCHEMBL6611092 | 0.88 | PDE4D (0.43) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6611085 | 0.88 | PDE4D (0.43) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6608418 | 0.84 | CHEK1 (0.35) | PDE4DPDE4BPDE4APDE4CCHEK1 | |
| SCHEMBL6605174 | 0.84 | CHEK1 (0.35) | PDE4DPDE4BPDE4APDE4CCHEK1 | |
| SCHEMBL6609471 | 0.83 | PDE4D (0.41) | PDE4DPDE4BPDE4APDE4CCHEK1 | |
| SCHEMBL6609466 | 0.83 | PDE4D (0.41) | PDE4DPDE4BPDE4APDE4CCHEK1 | |
| SCHEMBL6606520 | 0.83 | PDE4B (0.42) | PDE4DPDE4BPDE4APDE4CCHEK1 | |
| SCHEMBL6606526 | 0.83 | PDE4B (0.42) | PDE4DPDE4BPDE4APDE4CCHEK1 | |
| SCHEMBL6606783 | 0.79 | PDE4D (0.42) | PDE4DPDE4BPDE4APDE4CCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882714-B1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS PHARMACEUTICAL CO (JP) | 2004-03-03 | — | — | EP | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |