Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | DPP4 | P27487 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11240555 | 0.84 | THRB (0.57) | THRBMAPK1TP53MAPTDPP4 | |
| SCHEMBL19783662 | 0.82 | THRB (0.45) | THRBMAPK1MAPTDPP4GAA | |
| SCHEMBL6201155 | 0.82 | THRB (0.45) | THRBMAPK1MAPTGAARAD52 | |
| SCHEMBL6732648 | 0.79 | ALDH1A1 (0.50) | THRBMAPK1MAPTNPC1ALDH1A1 | |
| SCHEMBL6610256 | 0.78 | RAD52 (0.48) | MAPK1TP53MAPTGAARAD52 | |
| SCHEMBL6732335 | 0.78 | THRB (0.42) | THRBMAPK1MAPTDPP4GAA | |
| SCHEMBL6288997 | 0.75 | KMT2A (0.45) | MAPK1TP53MAPTDPP4NPC1 | |
| SCHEMBL538577 | 0.75 | KMT2A (0.46) | MAPTDPP4GAANPC1KDM4E | |
| SCHEMBL6200613 | 0.74 | KMT2A (0.45) | MAPTDPP4GAANPC1KDM4E | |
| SCHEMBL730189 | 0.74 | MAPK1 (0.46) | THRBMAPK1TP53MAPTDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456208-A1 | PYRIDOQUINOXALINE ANTIVIRALS | PHARMACIA & UPJOHN COMPANY (US) | 2004-09-15 | — | — | EP | disclosed |
| US-20040106596-A1 | Pyridoquinoxaline antivirals | PERRAULT WILLIAM R (US) | 2004-06-03 | — | — | US | disclosed |
| US-6686356-B2 | HERPES VIRUS | PHARMACIA & UPJOHN COMPANY | 2004-02-03 | — | — | US | disclosed |
| US-20030130255-A1 | PYRIDOQUINOXALINE ANTIVIRALS | PHARMACIA & UPJOHN COMPANY | 2003-07-10 | — | — | US | disclosed |
| WO-2003053972-A1 | PYRIDOQUINOXALINE ANTIVIRALS | PHARMACIA & UPJOHN COMPANY (US) | 2003-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106596-A1 | Pyridoquinoxaline antivirals | IFNAR1, ZC3HAV1, SARS1 | THRB 4529/4885MAPK1 291/4885TP53 2600/4885 |
| US-20030130255-A1 | PYRIDOQUINOXALINE ANTIVIRALS | IFNAR1, ZC3HAV1, SARS1 | THRB 4529/4885MAPK1 291/4885TP53 2600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.