SCHEMBL6608620

SCHEMBL6608620

O=C1OC(CCc2ccccc2)(c2ccccc2)CC(O)=C1SCc1cccc2ccccc12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LDHA P00338 4/20 0.42
CYP1A2 P05177 3/20 0.37
HPGD P15428 3/20 0.37
ALDH1A1 P00352 2/20 0.37
CYP2C9 P11712 2/20 0.37
CYP2C19 P33261 2/20 0.37
CYP2D6 P10635 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
POLB P06746 2/20 0.36
FFAR1 O14842 1/20 0.36
KMT2A Q03164 4/20 0.35
MEN1 O00255 2/20 0.35
UTS2R Q9UKP6 1/20 0.35
LDHB P07195 1/20 0.34
SLC12A2 P55011 1/20 0.33
SLC12A5 Q9H2X9 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
MCL1 Q07820 1/20 0.33
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6606612 0.86 LDHA (0.49) LDHALDHBL3MBTL1
SCHEMBL6603325 0.85 LDHA (0.53) LDHALDHBL3MBTL1
SCHEMBL6603173 0.84 LDHA (0.45) LDHAUTS2RLDHBL3MBTL1
SCHEMBL8342282 0.83 LDHA (0.41) LDHAALDH1A1SMN1; SMN2NPSR1FFAR1
SCHEMBL6602927 0.83 LDHA (0.41) LDHAHPGDALDH1A1POLBLDHB
SCHEMBL6607939 0.82 LDHA (0.50) LDHALDHBL3MBTL1
SCHEMBL6605927 0.80 LDHA (0.47) LDHAHPGDALDH1A1SMN1; SMN2KMT2A
SCHEMBL6606818 0.80 LDHA (0.43) LDHAHPGDALDH1A1POLBKMT2A
SCHEMBL7446994 0.80 LDHA (0.44) LDHASMN1; SMN2NPSR1POLBKMT2A
SCHEMBL7446287 0.80 LDHA (0.44) LDHACYP1A2ALDH1A1CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1142887-B1 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents PARKE DAVIS & CO (US) 2004-04-07 EP disclosed
EP-0729463-B1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & CO (US) 2002-05-22 EP disclosed
EP-1142887-A1 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents PARKE, DAVIS & COMPANY (US) 2001-10-10 EP disclosed
US-5936128-A BENZENETHIOL COMPOUNDS AS INTERMEDIATES; BACTERICIDES, VIRICIDES; HIV WARNER-LAMBERT COMPANY (US) 1999-08-10 US disclosed
US-5840751-A ADMINISTERING IN THE TREATMENT OF INFECTION OR DISEASE CAUSED BY A RETROVIRUS WARNER-LAMBERT COMPANY (US) 1998-11-24 US disclosed
US-5789440-A 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents WARNER-LAMBERT COMPANY (US) 1998-08-04 US disclosed
EP-0729463-A1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & COMPANY (US) 1996-09-04 EP disclosed
WO-1995014012-A1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed
WO-1995014011-A2 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed