Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.65 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | STS | P08842 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3843148 | 0.96 | NAMPT (0.66) | NAMPTGPR119KDM4EPKMSTS | |
| Acetic Acid SCHEMBL29880486 | 0.93 | NAMPT (0.63) | NAMPTGPR119KDM4EPKMSTS | |
| Trifluoroacetic Acid SCHEMBL29880449 | 0.89 | NAMPT (0.60) | NAMPTGPR119KDM4EPKMSTS | |
| SCHEMBL22050474 | 0.88 | NAMPT (0.64) | NAMPTGPR119KDM4EPKMSTS | |
| SCHEMBL22051946 | 0.88 | NAMPT (0.64) | NAMPTGPR119KDM4EPKMSTS | |
| SCHEMBL23951735 | 0.87 | TP53 (0.59) | NAMPTGPR119KDM4EPKMPOLB | |
| SCHEMBL1751432 | 0.87 | TP53 (0.59) | NAMPTGPR119KDM4EPKMPOLB | |
| SCHEMBL697513 | 0.87 | TP53 (0.59) | NAMPTGPR119KDM4EPKMPOLB | |
| SCHEMBL31616130 | 0.85 | NAMPT (0.61) | NAMPTGPR119KDM4EPKMSTS | |
| SCHEMBL24350753 | 0.85 | GPR119 (0.55) | NAMPTGPR119KDM4EPKMSTS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119551-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1433783-A2 | Naphthalenecarboxamides as tachykinin receptor antagonists | AstraZeneca AB (SE) | 2004-06-30 | — | — | EP | disclosed |
| US-6365602-B1 | FOR THERAPY OF DEPRESSION, ANXIETY, ASTHMA, PAIN, INFLAMMATION, URINARY INCONTINENCE AND OTHER DISEASE CONDITIONS | ASTRA ZENECA AB (SE) | 2002-04-02 | — | — | US | disclosed |