Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | PPM1B | O75688 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8773168 | 0.94 | ITGB1 (0.36) | SMN1; SMN2ALDH1A1POLBITGB1ITGA4 | |
| SCHEMBL70158 | 0.77 | CHRM2 (0.39) | SMN1; SMN2POLBCHRM2CHRM4CHRM3 | |
| SCHEMBL19550447 | 0.74 | KDM4E (0.34) | POLBITGB1ITGA4 | |
| SCHEMBL14109637 | 0.74 | KDM4E (0.34) | POLBITGB1ITGA4 | |
| SCHEMBL7443339 | 0.73 | L3MBTL1 (0.40) | ALDH1A1PPM1BPTPN1PPP1CC | |
| SCHEMBL10652010 | 0.70 | ITGB1 (0.31) | ITGB1ITGA4 | |
| SCHEMBL3533041 | 0.67 | ITGB1 (0.34) | POLBITGB1ITGA4 | |
| SCHEMBL20450497 | 0.67 | ITGB1 (0.34) | POLBITGB1ITGA4 | |
| SCHEMBL20450494 | 0.67 | ITGB1 (0.34) | POLBITGB1ITGA4 | |
| SCHEMBL272354 | 0.66 | CHRM2 (0.48) | SMN1; SMN2POLBCHRM2CHRM4CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140895-B1 | THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-03-24 | — | — | EP | disclosed |
| EP-1140895-A2 | THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040576-A2 | THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-07-13 | — | — | WO | disclosed |