Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 4/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | MMP12 | P39900 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3082582 | 0.81 | RECQL (0.53) | PTGES2CA2CA1MMP8MMP12 | |
| SCHEMBL6606484 | 0.81 | PTGES2 (0.43) | PTGES2CA2CA1SMN1; SMN2 | |
| SCHEMBL507412 | 0.80 | EPHX2 (0.44) | EPHX2NR1H4DPP4PARP10PLA2G10 | |
| SCHEMBL5012329 | 0.77 | IDO1 (0.54) | PTGES2CA2CA1MMP8MMP12 | |
| SCHEMBL27804763 | 0.75 | PLA2G10 (0.48) | DPP4PARP10PLA2G10PLA2G2ACA2 | |
| SCHEMBL6608511 | 0.75 | RECQL (0.58) | DPP4PARP10PLA2G10PLA2G2ACA2 | |
| SCHEMBL2720492 | 0.74 | PLA2G10 (0.44) | EPHX2NR1H4DPP4PARP10PLA2G10 | |
| SCHEMBL3084510 | 0.73 | TSHR (0.47) | CA2CA1TSHR | |
| SCHEMBL5458574 | 0.72 | CA2 (0.53) | CA2CA1ALDH1A1LMNATSHR | |
| SCHEMBL507413 | 0.71 | DPP4 (0.43) | DPP4PARP10PLA2G10PLA2G2ACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368327-B1 | BENZO THIADIAZINE MATRIX METALLOPROTEINASE INHIBITORS | WARNER LAMBERT CO (US) | 2004-10-20 | — | — | EP | claimed |