Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | IGF2R | P11717 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609189 | 1.00 | MAPT (0.43) | MAPTKDM4ESMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6607249 | 0.92 | PDE4A (0.40) | MAPTKDM4ESMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6607238 | 0.92 | PDE4A (0.40) | MAPTKDM4ESMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6606444 | 0.87 | EGFR (0.44) | MAPTKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL6606448 | 0.87 | EGFR (0.44) | MAPTKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL6609083 | 0.85 | MAPT (0.46) | MAPTKDM4ESMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6609089 | 0.85 | MAPT (0.46) | MAPTKDM4ESMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6609662 | 0.83 | MAPT (0.41) | MAPTKDM4ESMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6609657 | 0.83 | MAPT (0.41) | MAPTKDM4ESMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6610871 | 0.82 | MAPT (0.44) | MAPTKDM4ESMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882714-B1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS PHARMACEUTICAL CO (JP) | 2004-03-03 | — | — | EP | disclosed |
| US-5935977-A | PHOSPHODIESTERASE IV INHIBITORS, TUMOR NECROSIS FACTOR-ALPHA PRODUCTION INHIBITORS; TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |