Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15228998 | 0.81 | RAB9A (0.45) | HTTRECQLP2RX7RAB9AMEN1 | |
| SCHEMBL18765685 | 0.78 | GAA (0.46) | HTTRECQLP2RX7RAB9AMEN1 | |
| SCHEMBL31592678 | 0.78 | GAA (0.46) | HTTRECQLP2RX7RAB9AMEN1 | |
| SCHEMBL17827972 | 0.76 | HTT (0.42) | HTTRECQLP2RX7CCR1CCR8 | |
| SCHEMBL20738703 | 0.76 | HTT (0.42) | HTTRECQLP2RX7CCR1CCR8 | |
| SCHEMBL13915474 | 0.76 | HTT (0.42) | HTTRECQLP2RX7CCR1CCR8 | |
| SCHEMBL5769776 | 0.74 | NOS3 (0.42) | HTTRECQLP2RX7CCR1CCR8 | |
| SCHEMBL3724967 | 0.74 | NOS3 (0.42) | HTTRECQLP2RX7CCR1CCR8 | |
| SCHEMBL18308989 | 0.74 | NOS3 (0.42) | HTTRECQLP2RX7CCR1CCR8 | |
| SCHEMBL15244893 | 0.74 | SCN9A (0.41) | HTTMEN1KMT2AMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458719-A1 | PYRIDOQUINOXALINE ANTIVIRALS | PHARMACIA & UPJOHN COMPANY (US) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003053971-A1 | PYRIDOQUINOXALINE ANTIVIRALS | PHARMACIA & UPJOHN COMPANY (US) | 2003-07-03 | — | — | WO | disclosed |