Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.55 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.55 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.55 |
| ▸ | MDM2 | Q00987 | 5/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TGM2 | P21980 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609434 | 1.00 | CDYL2 (0.55) | CDYL2CDYLCDY1; CDY1BMDM2LRRK2 | |
| SCHEMBL4994071 | 0.89 | CDYL2 (0.68) | CDYL2CDYLCDY1; CDY1BMDM2LRRK2 | |
| SCHEMBL4994078 | 0.89 | CDYL2 (0.68) | CDYL2CDYLCDY1; CDY1BMDM2LRRK2 | |
| SCHEMBL4992385 | 0.80 | ALDH1A1 (0.54) | ALDH1A1MAPK1HSD17B10TGM2RET | |
| SCHEMBL4992393 | 0.80 | ALDH1A1 (0.54) | ALDH1A1MAPK1HSD17B10TGM2RET | |
| SCHEMBL11887935 | 0.80 | ALDH1A1 (0.60) | CDYL2CDYLCDY1; CDY1BMDM2ALDH1A1 | |
| SCHEMBL4990472 | 0.80 | MDM2 (0.61) | CDYL2CDYLCDY1; CDY1BMDM2LRRK2 | |
| SCHEMBL4994789 | 0.80 | ALDH1A1 (0.60) | CDYL2CDYLCDY1; CDY1BMDM2ALDH1A1 | |
| SCHEMBL4990478 | 0.80 | MDM2 (0.61) | CDYL2CDYLCDY1; CDY1BMDM2LRRK2 | |
| SCHEMBL4994792 | 0.80 | ALDH1A1 (0.60) | CDYL2CDYLCDY1; CDY1BMDM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430048-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | Allergan, Inc. (US) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003027102-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2003-04-03 | — | — | WO | disclosed |