Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.50 |
| ▸ | KIF20A | O95235 | 5/20 | 0.50 |
| ▸ | CLK1 | P49759 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609810 | 1.00 | KDM4E (0.52) | KDM4ENPC1RAB9APOLBDYRK1A | |
| SCHEMBL6606089 | 0.88 | MAPT (0.39) | KDM4ENPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL6606084 | 0.88 | MAPT (0.39) | KDM4ENPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL6605947 | 0.83 | KDM4E (0.53) | KDM4ENPC1RAB9APOLBDYRK1A | |
| SCHEMBL6605953 | 0.83 | KDM4E (0.53) | KDM4ENPC1RAB9APOLBDYRK1A | |
| SCHEMBL6605938 | 0.83 | FFAR4 (0.36) | KDM4ENPC1RAB9APOLBDYRK1A | |
| SCHEMBL6605936 | 0.83 | FFAR4 (0.36) | KDM4ENPC1RAB9APOLBDYRK1A | |
| SCHEMBL6611085 | 0.81 | PDE4D (0.43) | PDE4D | |
| SCHEMBL6611092 | 0.81 | PDE4D (0.43) | PDE4D | |
| SCHEMBL6605193 | 0.81 | PDE4D (0.51) | KDM4EPOLBSMN1; SMN2RECQLHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882714-B1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS PHARMACEUTICAL CO (JP) | 2004-03-03 | — | — | EP | disclosed |
| US-5935977-A | PHOSPHODIESTERASE IV INHIBITORS, TUMOR NECROSIS FACTOR-ALPHA PRODUCTION INHIBITORS; TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |